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中华细胞与干细胞杂志(电子版) ›› 2017, Vol. 07 ›› Issue (03) : 159 -161. doi: 10.3877/cma.j.issn.2095-1221.2017.03.007

所属专题: 文献

临床经验

外周静脉输注脐带间充质干细胞致血栓形成临床研究
陈丰穗1, 吴志贤1, 蔡锦全2, 高霞2, 谭建明2,()   
  1. 1. 350025 福州总医院肝胆内科
    2. 350025 福州总医院泌尿外科
  • 收稿日期:2016-11-16 出版日期:2017-06-01
  • 通信作者: 谭建明
  • 基金资助:
    中国博士后基金(2016M590597); 福建省自然科学基金面上项目(2016J01583); 福建省科技创新联合资金项目(2016Y9063)

Thromboembolism induced by umbilical cord mesenchymal stem cell infusion

Fengsui Chen1, Zhixian Wu1, Jinquan Cai2, Xia Gao2, Jianming Tan2,()   

  1. 1. Department of Hepatobiliary Disease, Fuzhou General Hospital, Fuzhou 350025, China
    2. Department of Urology, Fuzhou General Hospital, Fuzhou 350025, China
  • Received:2016-11-16 Published:2017-06-01
  • Corresponding author: Jianming Tan
  • About author:
    Corresponding author:Tan Jianming, Email:
引用本文:

陈丰穗, 吴志贤, 蔡锦全, 高霞, 谭建明. 外周静脉输注脐带间充质干细胞致血栓形成临床研究[J/OL]. 中华细胞与干细胞杂志(电子版), 2017, 07(03): 159-161.

Fengsui Chen, Zhixian Wu, Jinquan Cai, Xia Gao, Jianming Tan. Thromboembolism induced by umbilical cord mesenchymal stem cell infusion[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2017, 07(03): 159-161.

目的

探讨在干细胞的临床应用中,细胞输注后因血液介导的炎症反应,诱发血栓形成的现象及其治疗和预防策略。

方法

两例分别为肾移植术后和慢性肾脏疾病的患者,在输注脐带间充质干细胞后出现了血栓形成,采集临床表现和实验室检查资料并进行分析。

结果

通过外周静脉输注干细胞后,患者出现了前臂的疼痛和肿胀。彩超显示距穿刺部位较远距离静脉血栓形成,使用尿激酶和华法林进行溶栓治疗后,肿胀和疼痛得到缓解。

结论

血栓形成是干细胞临床治疗的一个重要安全性问题,应予以重视并采取充分的预防措施。

Objective

To investigate the thromboembolism induced by blood-mediated inflammatory reactions against infused cells during the clinical application of stem cells.

Methods

Two patients with renal transplantation and chronic kidney disease, respectively experienced thromboembolism after umbilical cord mesenchymal stem cell (UCMSC) infusion. The clinical manifestations and the laboratory test results were collected and analyzed.

Results

The patients received stem cell infusion through the peripheral veins and presented with a swollen and painful forearm post-infusion. Doppler ultrasound showed venous clots at the proximal end of the puncture site. Urokinase and warfarin were used for thrombolytic therapy. The swelling and pain were relieved and cured.

Conclusion

Thromboembolism in stem cell therapy should be prevented appropriately

图1 彩超下观察二例患者右肱静脉
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